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Effect of target secondary structure on RNAi efficiency.

Yu Shao1, Chi Yu Chan, Anil Maliyekkel

  • 1Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA.

RNA (New York, N.Y.)
|August 9, 2007
PubMed
Summary

Small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) efficiency in gene knockdown is improved by considering target accessibility and duplex asymmetry. These factors significantly enhance RNA interference (RNAi) efficacy for better gene silencing outcomes.

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