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Related Experiment Video

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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Potential etiologic agents in sarcoidosis.

David R Moller¹

¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. dmoller@jhmi.edu

Proceedings of the American Thoracic Society

|August 9, 2007

Summary

The cause of sarcoidosis is unknown. Researchers identified Mycobacterium tuberculosis catalase-peroxidase (mKatG) as a target antigen in over 50% of patients, suggesting a mycobacterial role in some cases.

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Last Updated: Jul 13, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

Immunology
Microbiology
Pulmonology

Background:

The etiology of sarcoidosis, characterized by epithelioid granulomas, remains elusive.
The Kveim reaction, where granulomas form after injecting sarcoid tissue homogenates, offers clues to potential etiologic agents.
Understanding sarcoidosis pathogenesis requires identifying antigens that explain its clinical and immunopathologic features.

Purpose of the Study:

To identify candidate pathogenic tissue antigens in sarcoidosis using the Kveim reaction's properties.
To investigate a potential mycobacterial etiology for sarcoidosis without prior assumptions.
To validate identified antigens as targets of the adaptive immune response in sarcoidosis patients.

Main Methods:

Utilized a limited proteomics approach based on Kveim reagent properties.
Employed protein immunoblotting with sarcoidosis sera to detect antigens in sarcoidosis tissues.
Applied Matrix-associated laser desorption/ionization-time of flight mass spectrometry for antigen identification.

Main Results:

Detected poorly soluble antigenic proteins in sarcoidosis tissues.
Identified Mycobacterium tuberculosis catalase-peroxidase (mKatG) as a key antigen.
Found IgG responses to mKatG in over 50% of sarcoidosis patients, but rarely in controls.

Conclusions:

mKatG is a sarcoidosis tissue antigen and a target of adaptive immunity.
These findings provide evidence for a mycobacterial etiology in a subset of sarcoidosis cases.
The methodology can be applied to discover antigens in other granulomatous disorders.