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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...

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Related Experiment Video

Updated: Jul 13, 2026

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.
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A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

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Push/pull hemodiafiltration.

Toru Shinzato1, Kenji Maeda

  • 1Daiko Medical Engineering Research Institute, Nagoya, Japan.

Contributions to Nephrology
|August 9, 2007
PubMed
Summary

Push/pull hemodiafiltration offers improved removal of uremic toxins compared to hemodialysis, potentially alleviating symptoms like restless legs syndrome and insomnia by clearing substances larger than beta-2 microglobulin.

Area of Science:

  • Nephrology
  • Renal Replacement Therapy
  • Biomedical Engineering

Background:

  • Hemodialysis is a common treatment for kidney failure.
  • Uremic toxins can accumulate and cause various symptoms.
  • Push/pull hemodiafiltration is an alternative therapy aiming for enhanced toxin removal.

Purpose of the Study:

  • To evaluate the efficacy of push/pull hemodiafiltration in removing uremic toxins.
  • To compare push/pull hemodiafiltration with conventional hemodialysis.
  • To assess the impact of push/pull hemodiafiltration on patient-reported symptoms.

Main Methods:

  • Push/pull hemodiafiltration involves alternating filtration and backfiltration cycles.
  • High-flux polysulfone hemodiafilters were used.

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Last Updated: Jul 13, 2026

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.
12:11

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

Published on: July 9, 2012

  • Beta-2 microglobulin reduction rates were measured.
  • Patient symptoms were monitored before and after treatment modality switch.

    • Main Results:

    • Push/pull hemodiafiltration showed a greater reduction rate of beta-2 microglobulin than hemodialysis, though the difference was small with modern filters.
    • Symptoms such as restless legs syndrome, irritability, insomnia, and pruritus were alleviated after switching to push/pull hemodiafiltration.
    • This suggests the accumulation of uremic substances larger than beta-2 microglobulin contributes to these symptoms.

    Conclusions:

    • Push/pull hemodiafiltration is functionally similar to predilution hemodiafiltration.
    • The therapy may be more effective in removing larger uremic toxins, leading to symptom improvement.
    • Further research is needed to fully elucidate the mechanisms and benefits of push/pull hemodiafiltration.