Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics, Attitudes and Preferences of an End-Stage Kidney Disease Population at the Beginning of an Exercise Program: A Pragmatic Multicenter Trial.

Journal of clinical medicine·2026
Same author

The Phosphate/Urea Nitrogen Ratio in Urine-A Method to Assess the Relative Intake of Inorganic Phosphate.

Nutrients·2025
Same author

An Immuno-Fragile Profile Is Associated with Mortality Risk in Patients with Chronic Kidney Disease.

Biomedicines·2025
Same author

New biomarkers of inflammation associated with haemodialysis.

Clinical kidney journal·2025
Same author

Fluorinated Zirconium-Based Metal-Organic Frameworks as Novel Sorbents to Improve the Efficacy of Hemodialysis Treatment.

Small science·2025
Same author

The true cost of phosphate control in chronic kidney disease.

Clinical kidney journal·2025

Related Experiment Video

Updated: Jul 13, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Inflammation and hemodiafiltration.

Rafael Ramirez1, Alejandro Martin-Malo, Pedro Aljama

  • 1Department of Nephrology, Hospital Reina Sofi a, Cordoba, Spain.

Contributions to Nephrology
|August 9, 2007
PubMed
Summary

Online hemodiafiltration (OL-HDF) reduces inflammatory dendritic cells and improves endothelial function in chronic kidney disease (CKD) patients. This dialysis method may mitigate microinflammation, reducing endothelial damage and promoting repair.

Area of Science:

  • Nephrology
  • Immunology
  • Cardiovascular Medicine

Background:

  • Cardiovascular diseases and atherosclerosis are leading causes of mortality in chronic kidney disease (CKD) patients.
  • CKD is characterized by chronic microinflammation, closely linked to atherosclerosis.
  • Hemodiafiltration (HDF) removes a broader range of uremic toxins compared to standard hemodialysis.

Purpose of the Study:

  • To investigate the impact of online hemodiafiltration (OL-HDF) on inflammatory markers and endothelial function in CKD patients.
  • To compare the effects of OL-HDF with high-flux hemodialysis (HF-HD) on monocyte-derived dendritic cells and endothelial microparticles.

Main Methods:

  • Patients with CKD underwent OL-HDF, a dialysis modality using high fluid substitution for enhanced toxin clearance.

Related Experiment Videos

Last Updated: Jul 13, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

  • Assessed the number and proinflammatory potential of CD14+CD16+ monocyte-derived dendritic cells.
  • Measured endothelial microparticles (EMP) and endothelial progenitor cells (EPC) in peripheral blood.

    • Main Results:

    • OL-HDF significantly reduced CD14+CD16+ dendritic cells and their proinflammatory potential in CKD patients.
    • OL-HDF improved endothelial dysfunction, decreasing EMP and increasing EPC compared to HF-HD.
    • Both studies showed reductions in dendritic cells, EMP, and EPC with OL-HDF versus HF-HD.

    Conclusions:

    • The microinflammation in CKD is associated with endothelial damage.
    • High convective transport via OL-HDF ameliorates chronic microinflammation, reducing endothelial damage and promoting repair.
    • Further research is needed to elucidate the mechanisms of these immunological changes and their impact on patient survival.