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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Tinnitus treatment with Trazodone.

Gabriel Cesar Dib1, Cristiane Akemi Kasse, Tatiana Alves de Andrade

  • 1EPM, UNIFESP.

Brazilian Journal of Otorhinolaryngology
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Trazodone did not effectively control tinnitus symptoms in a clinical trial. While patients reported improvements, there was no significant difference compared to placebo, though older adults showed some benefit.

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Area of Science:

  • Otolaryngology
  • Pharmacology
  • Clinical Neurology

Background:

  • Tinnitus is a prevalent condition characterized by auditory perception without external stimuli.
  • Serotonergic pathways are implicated in tinnitus, making antidepressants potential treatment candidates.

Purpose of the Study:

  • To investigate the efficacy of Trazodone, a serotonin-modulating antidepressant, in managing tinnitus.
  • To assess Trazodone's impact on tinnitus intensity, patient discomfort, and quality of life.

Main Methods:

  • A prospective, double-blind, randomized, placebo-controlled trial was conducted.
  • Eighty-five tinnitus patients received either Trazodone or a placebo for 60 days.
  • Outcomes were measured using a 0-10 analogue scale for tinnitus intensity, discomfort, and quality of life.

Main Results:

  • Both Trazodone and placebo groups showed significant improvements in tinnitus intensity, discomfort, and quality of life post-treatment.
  • No statistically significant difference in outcomes was observed between the Trazodone and placebo groups.
  • Patients aged 60 years and older demonstrated more favorable results following the treatment period.

Conclusions:

  • Trazodone, at the utilized dosages, was not found to be effective in controlling tinnitus.
  • Further research may be needed to explore Trazodone's role in specific tinnitus patient subgroups or at different dosages.