[Participation of reactive oxygen species in muscle damage produced by hypokinesis]

The big problem of high-developed community is hypokinesis - clinical state generated by long-lasting immobilization. Virtually all body systems are affected by immobilization. Hypokinesis intensify production of reactive oxygen species (ROS). The detoxification of ROS is especially important for muscles because myocytes are particularly weekly protecting against oxidative injury. Hypokinesis is a case of increase lipid peroxydation process in muscle tissue and increase aggregation of thrombocytes and high decreased of antioxidative enzymes (superoxide dismutase, glutatione peroxide, catalase) and concentration of vitamin E in blood. As a result muscle lost mass with receptivity on thrombosis. Rehabilitation is very important because it activated antioxidant defense system to detoxification ROS. Supplementation by antioxidative vitamins and antithrombosis treatment are very helpful.