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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

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Published on: October 18, 2011

Changes in cognitive functioning in the year after hematopoietic stem cell transplantation.

Sheri R Jacobs¹, Brent J Small, Margaret Booth-Jones

¹Health Outcomes and Behavior Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

|August 10, 2007

Summary

Hematopoietic stem cell transplantation (HSCT) candidates experience cognitive deficits pre-transplant. Cognitive functioning, except attention, significantly improves and returns to normal within one year post-HSCT.

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Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Area of Science:

Neuroscience
Hematology
Psychology

Background:

Hematopoietic stem cell transplantation (HSCT) can impact cognitive functions.
Cognitive deficits are often observed in HSCT candidates before the procedure.

Purpose of the Study:

To examine changes in cognitive functioning domains in HSCT candidates.
To assess cognitive performance at pre-transplantation, 6 months, and 12 months post-transplantation.

Main Methods:

A sequential longitudinal design with 476 randomized patients.
Comprehensive neuropsychological testing of memory, psychomotor speed, attention, and executive functioning.
Calculation of a total neuropsychological performance score (TNP).

Main Results:

Cognitive abilities, excluding attention, showed significant improvement 1 year after HSCT.
Total neuropsychological performance and most cognitive domains met or exceeded population norms by 12 months.
Repeated testing improved motor speed and TNP; attrition impacted TNP, favoring those remaining in the study.

Conclusions:

HSCT candidates experience pre-transplant cognitive deficits.
Cognitive functioning generally recovers to normative levels within one year following HSCT.
Longitudinal improvements are observed, though influenced by sample attrition.