Selective expression of LDLR and VLDLR in myelinating oligodendrocytes

Oligodendrocytes form myelin sheaths around axons in the central nervous system. Although cholesterol is one of the major lipid components in myelin sheath, the source of cholesterol for myelination remains to be defined. In this study, we report that low-density lipoprotein receptor (LDLR) and very low-density lipoprotein receptor (VLDLR) are selectively expressed in mature myelinating oligodendrocytes in the postnatal CNS. Both receptors are specifically expressed in differentiated oligodendrocytes in P7 spinal cord, but progressively down-regulated after P15. In adult animals, only LDLR expression can be detected in a small number of oligodendrocytes throughout the entire spinal cord. In the brain region, LDLR is expressed by the white matter oligodendrocytes of both cerebellum and cerebral cortex, whereas VLDLR has a weak expression in cerebellar oligodendrocytes. Together, our expression studies suggest that cholesterol uptake by LDLR and VLDLR may play an important role in the formation of myelin sheath.