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Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Pore Transport and Ion-Pair Transport01:17

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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...

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Related Experiment Video

Updated: Jul 13, 2026

Live Imaging Assay for Assessing the Roles of Ca2+ and Sphingomyelinase in the Repair of Pore-forming Toxin Wounds
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Diffusion in coiled pores - learning from microrelease and microsurgery.

Magdalena Stempniewicz1, Ahmed S G Khalil, Michael Rohwerder

  • 1Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.

Journal of the American Chemical Society
|August 10, 2007
PubMed
Summary

Anisotropic diffusion in coiled pore systems was studied. Microsurgery techniques revealed challenges with focused ion beams (FIB) sealing mesopores instead of opening them.

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Last Updated: Jul 13, 2026

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Published on: August 25, 2013

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Area of Science:

  • Materials Science
  • Physical Chemistry
  • Nanotechnology

Background:

  • Hierarchical structuring significantly influences material properties.
  • SBA-3 type microparticles exhibit complex coiled pore systems.
  • Understanding guest molecule diffusion is key to characterizing porous materials.

Purpose of the Study:

  • To investigate anisotropic diffusion within SBA-3 microparticle coiled pore systems.
  • To analyze the impact of hierarchical structure on diffusion dynamics.
  • To evaluate mesopore modification techniques for altering diffusion pathways.

Main Methods:

  • Guest molecule release studies to probe diffusion.
  • Optical microscopy for identifying and measuring diffusion modes.
  • Mesopore opening via focused ion beams (FIB) and mechanical tools.

Main Results:

  • Two distinct diffusion modes were identified: along and across mesopores.
  • Focused ion beam (FIB) treatment, intended for pore opening, inadvertently sealed mesopores.
  • Mechanical tools provided a more controlled method for mesopore modification.

Conclusions:

  • Anisotropic diffusion in hierarchical pore systems is complex.
  • FIB microsurgery poses risks of misinterpretation due to unintended sealing effects.
  • Controlled mesopore modification is crucial for tuning diffusion properties in microparticles.