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Age-related changes in ocular aberrations with accommodation.

Hema Radhakrishnan1, W Neil Charman

  • 1Faculty of Life Sciences, University of Manchester, Manchester, UK. Hema.Radhakrishnan@manchester.ac.uk

Journal of Vision
|August 10, 2007
PubMed
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Age-related changes in eye aberrations were studied during monocular accommodation. Spherical aberration shifts positively with age, while younger individuals show a decrease with accommodation, unlike older subjects.

Area of Science:

  • Ophthalmology
  • Optometry
  • Physiological Optics

Background:

  • Ocular aberrations, particularly higher-order aberrations, affect visual quality.
  • Accommodation, the eye's ability to change focus, can influence these aberrations.
  • Age-related changes in the crystalline lens may impact both accommodation and aberrations.

Purpose of the Study:

  • To investigate how ocular aberrations change with age during monocular accommodation.
  • To analyze the relationship between accommodative demand and higher-order aberrations across different age groups.

Main Methods:

  • Measured second-order and higher-order wavefront aberrations and pupil size in 47 subjects (17-56 years).
  • Assessed aberrations for natural pupil sizes and fixed pupil diameters (4.5 mm unaccommodated, 2.5 mm accommodated).

Related Experiment Videos

  • Analyzed Zernike aberrations, focusing on spherical aberration (C4(0)) and RMS error.

    • Main Results:

    • Spherical aberration (C4(0)) increased positively with age in relaxed accommodation.
    • Active accommodation caused spherical aberration to decrease and become negative in subjects under 40.
    • Older subjects (>40 years) exhibited minimal changes in spherical aberration with accommodation.

    Conclusions:

    • Age-related changes in the crystalline lens's refractive index and curvature influence the interplay between aberrations and accommodation.
    • Understanding these age-dependent accommodative aberration changes is crucial for visual optics and ophthalmic lens design.