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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Combination therapy with renin-angiotensin system blockers: will amlodipine replace hydrochlorothiazide?
Thor Tejada1, Alessia Fornoni, Oliver Lenz
1Division of Nephrology and Hypertension, Department of Medicine, Miller School of Medicine, University of Miami OPPRP (D-54), PO Box 016960, Miami, FL 33101, USA.
Abstract:
Amlodipine is a highly effective and safe antihypertensive dihydropyridine calcium channel blocker. It is even more effective when used in combination with other antihypertensive medications, including hydrochlorothiazide. When antihypertensive calcium channel blockers were first introduced, evidence in the laboratory that they had some natriuretic properties was adduced to suggest that they would be "the diuretics of the 1990s." This turned out not to be the case. Because of its clinical efficacy, amlodipine is frequently used in fixed-dose combination products, but it is not likely to replace hydrochlorothiazide.
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