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Related Experiment Video

Updated: Jul 13, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Smoking, aging and the centenarians.

V Nicita-Mauro¹, C Lo Balbo, A Mento

¹Cattedra di Geriatria e Gerontologia, Scuola di Specializzazione in Geriatria, Università degli Studi di Messina, Azienda Ospedaliera Universitaria Policlinico G. Martino, I-98125 Messina, Italy. nicitav@unime.it

Experimental Gerontology

|August 10, 2007

Summary

Cigarette smoking accelerates aging and disease, reducing life expectancy and quality of life. Quitting smoking, even in old age, improves survival by reducing biological damage.

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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

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Area of Science:

Gerontology
Public Health
Toxicology

Background:

Cigarette smoke accelerates aging via free radicals and disease risk.
Smoking is a major risk factor for cancer, cardiovascular, and respiratory diseases.
Smoking negatively impacts life expectancy and quality of life, increasing dependency.

Purpose of the Study:

To examine the impact of cigarette smoking on the aging process and longevity.
To highlight the benefits of smoking cessation on healthspan and lifespan.
To emphasize the role of healthcare professionals in promoting smoking abstinence.

Main Methods:

Review of existing literature on smoking, aging, and disease.
Analysis of health outcomes in smokers versus non-smokers.
Observation of smoking prevalence and health status in centenarians.

Main Results:

Smokers have significantly lower life expectancy than non-smokers.
Smoking cessation improves survival rates, even in the elderly, by reducing biological damage.
Extreme longevity (centenarians) is rarely associated with smoking; when present, it correlates with poor health.

Conclusions:

Cigarette smoking detrimentally affects longevity and healthspan.
Smoking cessation is crucial for delaying disease, promoting aging well, and achieving longevity.
Healthcare providers should advocate for smoking abstinence as a cornerstone of a healthy lifestyle.