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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
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[Interferon in the treatment of viral hepatitis. The interferon was discovered 50 years ago]

János Fehér1, Gabriella Lengyel

  • 1Semmelweis Egyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088. feher@bel2.sote.hu

Orvosi Hetilap
|August 10, 2007
PubMed

The interferons are heterogenic glycoproteins which are produced on the effect of virus infection, as immune answer, by the living cells. They were discovered half a century ago. They have antineoplastic, antiviral and immunomodulator effect. The names of interferons used in the therapy are nominated with Greek letters. This nomination shows their origins: the interferon-alpha originates from leucocytes, the interferon-beta does from fibroblasts and the interferon-gamma is produced as immune interferon by lymphocytes. In human medicine both natural and recombinant interferons are applied. The connection of polyethyleneglycol to interferons ensures their sustained effect. Nowadays they are applied in the therapy of chronic hepatitis B or C as well as in oncology to inhibit the neoplasm progression.

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