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Tranexamic acid-associated ligneous conjunctivitis with gingival and peritoneal lesions
J P Diamond1, A Chandna, C Williams
1Bristol Eye Hospital.
The British Journal of Ophthalmology
|December 1, 1991
Summary
Ligneous conjunctivitis, typically caused by various agents, can also be a rare side effect of tranexamic acid, an anti-fibrinolytic drug. This case highlights potential systemic complications beyond the eyes, including gingival and peritoneal lesions.
Area of Science:
- Ophthalmology
- Pharmacology
- Internal Medicine
Background:
- Ligneous conjunctivitis is a rare condition characterized by thick, woody exudates.
- Multiple etiological agents have been implicated in its development.
- Tranexamic acid is an antifibrinolytic agent commonly used for menorrhagia and other bleeding disorders.
Observation:
- A patient developed ligneous conjunctivitis.
- The condition was identified as a potential side effect of tranexamic acid therapy.
- Additional clinical manifestations included gingival and peritoneal lesions.
Findings:
- The patient exhibited typical conjunctival changes associated with ligneous conjunctivitis.
- Unusual involvement of the gingiva and peritoneum was noted.
- Peritoneal lesions led to significant protein loss into the peritoneal cavity.
Implications:
- This case suggests tranexamic acid as a novel potential cause of ligneous conjunctivitis.
- The findings broaden the understanding of potential adverse effects of tranexamic acid.
- Systemic complications, including protein-losing enteropathy secondary to peritoneal involvement, should be considered in patients on tranexamic acid presenting with conjunctival lesions.