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Intracerebral haemorrhage due to acquired factor XIII inhibitor--successful response to factor XIII concentrate

H M Daly1, P J Carson, J K Smith

  • 1Department of Haematology, Royal Cornwall Hospital (Treliske), Truro, UK.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|August 1, 1991
PubMed

A 63-year-old woman presented with extensive bruising. An inhibitor to factor XIII was detected. Subsequent subcutaneous bruising and soft tissue haemorrhage into the left foot were treated with infusions of pasteurized factor XIII concentrate with good effect. Immunosuppression with cyclophosphamide was attempted but in spite of this she suffered a right cerebral haemorrhage necessitating further intensive therapy with factor XIII concentrate. This overcame the inhibitor, adequate post-infusion factor XIII levels were achieved and she made an excellent recovery. Factor XIII concentrate was well tolerated with no evidence of transmission of hepatitis or HIV infection. The inhibitor appeared to interfere with haemostasis by hindering the fibrin binding site of factor XIII, resulting in interference in clot-solubility tests. Subsequently the inhibitor resolved.

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