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Updated: Jul 13, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
Mirtazapine for anorexia nervosa with depression
Nik Ruzyanei Nik Jaafar1, Tuti Iryani Mohd Daud, Fairuz Nazri Abdul Rahman
1Department of Psychiatry, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Kuala Lumpur, Cheras, Malaysia. nikruzyanei@yahoo.com
Objective:
To report the use of Mirtazapine in the treatment of anorexia nervosa with depression primarily regarding its propensity for weight gain.
Method:
We present an outpatient case report of anorexia nervosa with depression. The patient's subsequent progress was recorded.
Results:
The patient gained 2.5 kg within 3 months to eventually attain a body mass index of 15 after 5 months. Her depression achieved full remission at 6 weeks of treatment.
Conclusions:
Mirtazapine is the choice medication in this case. However, treating depression requires caution, given these patients' physical vulnerability. Controlled trials of Mirtazapine for anorexia nervosa are needed.
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