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Sleep-wake cycle disturbances in protein-energy malnutrition: effect of nutritional rehabilitation
S Y Shaaban1, H L Ei-Sayed, M F Nassar
1Department of Paediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract:
A standard sleep questionnaire was given to the parents of 26 infants with protein-energy malnutrition who underwent polysomnographic evaluation. These investigations were repeated approximately 2 months after enrolment in a nutritional rehabilitation programme based on World Health Organization guidelines. Anthropometric values and serum serotonin levels were also measured. After nutritional rehabilitation there was a significantly higher percentage of non-rapid eye movement (REM) sleep; 2nd REM time, and latency times for sleep and REM sleep increased. Percentages of REM sleep and serum serotonin levels decreased significantly. Protein-energy malnutrition seems to affect the sleep-wake cycle; disturbed serotonin levels may be among the factors responsible.
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