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[Immunologic and bacteriologic study of severe acute appendicitis. Diagnostics and therapeutic considerations]

D Voiculescu1, R Palade

  • 1Clinica Chirurgie I, Spitalul Universitar de Urgenţă Bucureşti. danvoiculescu@yahoo.com

Chirurgia (Bucharest, Romania : 1990)
|August 11, 2007
PubMed

Insights

Delayed diagnosis and treatment of acute appendicitis significantly increase complication risks. Prompt surgical intervention is crucial for better outcomes in this common surgical emergency.

Area of Science:

  • Microbiology
  • Surgical Pathology
  • Immunology

Context:

  • Acute appendicitis is a leading cause of acute abdomen globally.
  • Complications present significant therapeutic challenges.
  • This study analyzed 114 cases of acute appendicitis.

Purpose:

  • To investigate the pathogen flora and immune response in acute appendicitis.
  • To determine the relationship between microbial findings and pathological lesions.
  • To identify factors contributing to complications.

Summary:

  • Microbiological analysis revealed predominantly pluribacterial infections (89%), with aerobes and anaerobes frequently associated (85%).
  • Escherichia coli (87%) and Bacteroides (55%) were the most common pathogens identified.
  • No specific pathogenic germs or immune system malfunctions were found; time to diagnosis and surgery emerged as critical factors for complications.

Impact:

  • Highlights the critical role of timely diagnosis and surgical intervention in managing acute appendicitis.
  • Provides insights into the polymicrobial nature of appendicitis infections.
  • Emphasizes that complications are primarily linked to delays rather than specific microbial virulence or immune deficiency.

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