Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The molecular basis of positional information.

D Summerbell1, J C Smith, M Maden

  • 1Limb Development Group, National Institute for Medical Research, Mill Hill, London.

In Vivo (Athens, Greece)
|September 1, 1991
PubMed
Summary

Embryologists have long sought morphogens controlling embryonic development. Recent advances suggest key signalling molecules may finally be identified, offering insights into positional information.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development.

Development (Cambridge, England)·2001
Same author

The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors.

Development (Cambridge, England)·2000
Same author

A pre-coital pill? A preliminary in vitro study.

The British journal of family planning·2000
Same author

Transcriptional regulation during somitogenesis.

Current topics in developmental biology·2000
Same author

The segmental precision of the motor projection to the intercostal muscles in the developing chicken embryo. A differential labelling study using fluorescent tracers.

Anatomy and embryology·1995
Same author

Relationship between stimulated hyperactivated motility of human spermatozoa and pregnancy rate in donor insemination: a preliminary report.

Human reproduction (Oxford, England)·1994

Area of Science:

  • Developmental biology
  • Molecular embryology

Background:

  • For a century, embryologists have hypothesized morphogens guiding embryonic pattern formation.
  • Evidence has consistently pointed towards the existence of these crucial signalling molecules.

Purpose of the Study:

  • To review the current evidence for the molecular underpinnings of positional information in embryonic development.
  • To discuss the potential identification of key morphogens.

Main Methods:

  • Literature review of existing research on embryonic development and signalling molecules.
  • Analysis of evidence supporting the role of specific molecules in establishing positional information.

Main Results:

  • The review highlights significant progress in identifying potential morphogens.
  • Current evidence strongly supports the molecular basis of positional information.

Conclusions:

  • The identification of key morphogens controlling embryonic development is now a tangible possibility.
  • This research advances our understanding of developmental biology and molecular signalling.

Related Experiment Videos