Related Experiment Video
Updated: Sep 13, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
The molecular basis of positional information
D Summerbell1, J C Smith, M Maden
1Limb Development Group, National Institute for Medical Research, Mill Hill, London.
Abstract:
Embryologists have dreamed of their own particular philosophers stone for 100 years. During that time they have repeatedly demonstrated the likely existence of signalling molecules or morphogens that control the pattern of development in the embryo. Now at last seems possible that some of these morphogens may have been identified. We review current evidence for the molecular basis of positional information.
Related Concept Videos
Molecular Orbital Theory I
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Position-effect Variegation
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the timing and level of...
MO Theory and Covalent Bonding
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...

