Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Replacing animal experiments: choices, chances and challenges.

Gill Langley1, Tom Evans, Stephen T Holgate

  • 1Dr Hadwen Trust for Humane Research, Hitchin, Hertfordshire, UK. gill@drhadwentrust.org

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|August 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal boosting enhances genital tract T cell immunity following ChAdOx1/MVA hrHPV therapeutic vaccination.

NPJ vaccines·2026
Same author

Cognitive muscular therapy™ for knee osteoarthritis: A feasibility randomised controlled trial.

Osteoarthritis and cartilage open·2026
Same author

EEG Correlates of the Influence of Somatosensory Input, Expectations and Trait-Like Bias on Pain Perception.

European journal of pain (London, England)·2025
Same author

Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents.

Nature communications·2025
Same author

Air pollution and alveolar health.

European respiratory review : an official journal of the European Respiratory Society·2025
Same author

Soft porous metamaterials using inflation-induced buckling for smart actuation.

Nature communications·2025

The shift towards non-animal testing methods, including in vitro assays and computer modeling, is advancing scientific research. While academic animal use is rising, progress in replacing animal procedures is evident in various research fields.

Area of Science:

  • * Advancing scientific methodologies and ethical research practices.
  • * Focus on the development and implementation of alternative testing strategies.
  • * Interdisciplinary research spanning toxicology, pharmacology, and biomedical sciences.

Background:

  • * Legislative, scientific, and moral drivers are pushing for the replacement of animal procedures.
  • * Non-animal approaches offer advanced methods surpassing limitations of traditional animal experiments.
  • * In vitro assays have significantly reduced animal use in chemical and medicine testing.

Purpose of the Study:

  • * To evaluate the progress and challenges in replacing animal procedures with non-animal methods.
  • * To highlight the increasing acceptance and application of advanced alternative methods.
  • * To explore the potential of systematic reviews in driving novel non-animal approaches.

Related Experiment Videos

Main Methods:

  • * Utilizing cells and tissues in vitro, volunteer studies, physicochemical techniques, and computer modeling.
  • * Reviewing existing literature and systematic reviews on the transferability of animal data.
  • * Analyzing trends in academic animal use versus established non-animal applications.

Main Results:

  • * Significant reduction in animal use in chemical and medicine testing through in vitro assays.
  • * Continued rise in academic animal use, indicating resistance to replacement in some university research.
  • * Successful replacement of some animal procedures in neurological, reproductive, and dentistry research.

Conclusions:

  • * Non-animal methods are advanced and overcome many limitations of animal experiments.
  • * Systematic reviews can stimulate the search for novel non-animal methods.
  • * Increased funding is expected to accelerate advances in animal procedure replacement.