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Activation of immediate early genes after acute stress
S S Schreiber1, G Tocco, T J Shors
1Department of Neurology, University of Southern California, School of Medicine, Los Angeles 90033.
Neuroreport
|January 1, 1991
Abstract:
We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.