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A magnetic resonance image study of age-related changes in human putamen nuclei
W M McDonald1, M Husain, P M Doraiswamy
1Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Neuroreport
|January 1, 1991
Abstract:
Putamen nuclei were assessed in 36 normal volunteers using magnetic resonance imaging and a systematic sampling method. There was a significant decrease in the volume of the putamen nuclei with advancing age (r = -0.74, p less than 0.0001), and an associated decline in the volume of the caudate nuclei (r = 0.60, p less than 0.0001). The implications of these findings in age-associated motor abnormalities are discussed.