Phosphamidon neurotoxicity: protection by acetylhomocysteine thiolactone

The present study was undertaken to evaluate the neurotoxic effects of the organophosphate, phosphamidon, on glutathione-S-transferase (GST) activity and concentration of sulphhydryl groups, and to study the possible protection against these effects by the simultaneous administration of the antioxidant, acetylhomocysteine thiolactone, commonly known as citiolone. Significant depletion was observed in the GST activity as well as in the level of total and non-protein bound sulphhydryl groups in various CNS regions of phosphamidon-intoxicated rats. When citiolone was administered alone, there was a remarkable elevation in GST activity. However, significant protection against GST inhibition was observed when phosphamidon and citiolone were administered simultaneously.