Behavioural effects of selective A2 adenosine receptor antagonists, CGS 21197 and CGS 22706, in mice

The present data show that selective A2 adenosine receptor antagonists tended to increase locomotor and rearing activities in mice confronted with a free exploratory test. These findings support the hypothesis that the behavioural effects of adenosine antagonists can be linked to their actions at adenosine A2 receptors.