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Related Experiment Videos

Is a rhinovirus vaccine possible?

J P Fox

    American Journal of Epidemiology
    |April 1, 1976
    PubMed
    Summary

    Developing a rhinovirus (RV) vaccine is crucial due to RV

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    IMMUNITY TO YELLOW FEVER ENCEPHALITIS OF MONKEYS AND MICE IMMUNIZED BY NEURAL AND EXTRANEURAL ROUTES.

    The Journal of experimental medicine·2009

    Area of Science:

    • * Virology and Immunology
    • * Public Health and Epidemiology

    Background:

    • * Rhinovirus (RV) is a major cause of acute upper respiratory disease, particularly in children.
    • * Epidemiologic studies reveal common RV serotypes and the emergence of new serotypes through antigenic shift.
    • * Existing immunologic studies indicate significant antigenic cross-relations among RV serotypes.

    Purpose of the Study:

    • * To justify continued support for rhinovirus (RV) vaccine development.
    • * To identify common and emerging RV serotypes as targets for immunization.
    • * To explore RV serotype cross-relations for a broadly effective vaccine formulation.

    Main Methods:

    • * Analysis of epidemiologic surveillance data to identify prevalent and emerging RV serotypes.
    • * Systematic cross-testing of RV serotypes using monospecific antisera and rabbit immunization models.
    • * Review of existing studies on naturally occurring and experimentally induced RV infections in humans.

    Main Results:

    • * Certain RV serotypes are frequently encountered and persist, accounting for a disproportionate number of infections.
    • * An increase in higher-numbered and untypable RV serotypes suggests ongoing antigenic shift.
    • * Extensive antigenic cross-relations exist among RV serotypes, allowing for identification of closely related groups.

    Conclusions:

    • * The identified common and emerging RV serotypes, along with their cross-relations, provide a basis for developing a broadly effective vaccine.
    • * Further research into heterotypic responses and secretory antibody is warranted.
    • * Current knowledge supports the initiation of volunteer trials to assess vaccine efficacy.

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