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Updated: Jul 13, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
[Collagenous colitis. Clinicopathological study of 18 cases]
I de la Iglesia Fanjul1, M R de Castro Losa, F Izquierdo García
1Servicio de Medicina Interna, Hospital de León, León, España. delaidoc@hotmail.com
Collagenous colitis (CC) diagnosis requires multiple biopsies for chronic watery diarrhea, even with normal colonoscopy. Early identification of drug and autoimmune links aids management.
Area of Science:
- Gastroenterology
- Coloproctology
- Internal Medicine
Background:
- Collagenous colitis (CC) is an uncommon cause of chronic watery diarrhea with a generally favorable prognosis.
- Understanding its epidemiological and clinical features is crucial for timely diagnosis and management.
Purpose of the Study:
- To investigate the epidemiological and clinical characteristics of collagenous colitis.
- To analyze the disease course and treatment response in patients with collagenous colitis.
Main Methods:
- A retrospective descriptive study analyzed endoscopic colon biopsies over five years.
- Cases meeting histological criteria for collagenous colitis were selected for review.
Main Results:
- Eighteen cases of collagenous colitis were identified, with an incidence of 1.25 per 10(5) inhabitants/year.
- A significant delay in diagnosis (10 months) was observed.
- Potential associations with NSAID use (46%), lansoprazole (42.8%), smoking (41.6%), and autoimmune diseases (30.7%) were noted.
- Mesalazine and budesonide showed favorable treatment responses.
Conclusions:
- Multiple colon biopsies are essential for diagnosing collagenous colitis, especially in chronic watery diarrhea cases with normal colonoscopy findings.
- Certain medications and autoimmune conditions may contribute to the etiology of collagenous colitis.
- Prompt diagnosis and appropriate treatment contribute to a favorable clinical course.
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