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Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
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Related Experiment Video

Updated: Jul 13, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Wilms tumor: progress and considerations for the surgeon.

P F Ehrlich1

  • 1University of Michigan, Ann Arbor Michigan, Associate Professor of Surgery, Vice Chair Surgery Renal Tumors Committee, Childrens Oncology Group, USA. pehrlich@med.umich.edu

Surgical Oncology
|August 11, 2007
PubMed
Summary

Wilms tumor (WT), a common pediatric kidney cancer, now has an 85% survival rate due to risk-based management. Future treatments will tailor care based on patient-specific genetic markers and outcomes.

Related Experiment Videos

Last Updated: Jul 13, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Nephrology

Background:

  • Wilms tumor (WT) is the most common kidney cancer in children, representing 6% of all pediatric tumors.
  • Survival rates have dramatically improved from 30% to nearly 85% due to advancements in treatment.
  • Current treatment strategies are evolving towards risk-based management, incorporating genetic markers alongside traditional staging and histology.

Purpose of the Study:

  • To review recent treatment considerations for Wilms tumor.
  • To emphasize the critical role of the surgeon in diagnosis, staging, and guiding therapy for optimal outcomes.
  • To discuss the identification of patient subsets requiring tailored management based on survival and potential late effects.

Main Methods:

  • Review of current literature and treatment protocols for Wilms tumor.
  • Analysis of risk-based management strategies incorporating genetic markers.
  • Focus on the surgical contribution to diagnosis, staging, and therapeutic decision-making.

Main Results:

  • Wilms tumor survival rates have significantly improved, approaching 85% in major trials.
  • Risk-based management is the emerging standard, personalizing treatment based on stage, histology, and genetic factors.
  • Identifying specific patient subsets with distinct outcomes is crucial for refining treatment approaches.

Conclusions:

  • The surgeon's expertise is paramount in managing Wilms tumor, influencing diagnosis, staging, and patient outcomes.
  • Future Wilms tumor treatment will focus on personalized medicine, addressing subsets with poor survival or high risk of late effects.
  • Continued research into genetic markers and tailored management strategies will further enhance outcomes for children with Wilms tumor.