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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Published on: May 14, 2015

Human embryonic stem cells: current technologies and emerging industrial applications.

Caroline Améen¹, Raimund Strehl, Petter Björquist

¹Cellartis AB, Arvid Wallgrens Backe 20, 413 46 Göteborg, Sweden.

Critical Reviews in Oncology/Hematology

|August 11, 2007

Summary

Human embryonic stem (hES) cells offer revolutionary potential for drug discovery and regenerative medicine. This review explores hES cell technology for improved drug development, toxicity testing, and therapeutic applications.

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Area of Science:

Biomedical Research
Stem Cell Technology
Drug Development

Background:

Current drug development is hindered by the absence of functional human cell systems.
Human embryonic stem (hES) cell lines, derived in the late 1990s, possess pluripotency and differentiation capabilities.
hES cells represent a significant advancement for biomedical research and therapeutic strategies.

Purpose of the Study:

To review the fundamental science behind hES cell technology from an industrial viewpoint.
To discuss the current and future applications of hES cells in drug discovery and regenerative medicine.
To explore the potential of hES cells for enhanced toxicity testing and novel therapeutic interventions.

Main Methods:

Review of existing scientific literature on hES cell derivation and properties.
Analysis of industrial perspectives on hES cell applications.
Discussion of technological advancements and future prospects in stem cell research.

Main Results:

hES cells provide a versatile human cell system for research and development.
The unique properties of hES cells enable diverse applications in drug screening and toxicity assessment.
Significant potential exists for hES cell-based therapies in regenerative medicine.

Conclusions:

hES cell technology is poised to transform drug discovery and development pipelines.
Further research and industrial integration of hES cells will drive innovation in medicine.
hES cells offer a promising platform for advancing personalized medicine and regenerative therapies.