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Related Experiment Videos

Cognitive dysfunction with tolterodine use.

Stefano Salvatore1, Maurizio Serati, Linda Cardozo

  • 1Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Varese, Italy. stefanosalvatore@hotmail.com

American Journal of Obstetrics and Gynecology
|August 11, 2007
PubMed
Summary
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A 65-year-old woman experienced new-onset mental confusion while taking tolterodine for overactive bladder. Reducing the dosage resolved the confusion while still managing bladder symptoms.

Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Neurology

Background:

  • Overactive bladder (OAB) is a common condition affecting many individuals.
  • Tolterodine is a widely prescribed anticholinergic medication for OAB treatment.
  • Anticholinergic medications can have central nervous system side effects.

Observation:

  • A 65-year-old healthy female patient developed de novo mental confusion.
  • The confusion emerged during treatment with 2 mg of tolterodine administered twice daily.
  • This represents a rare complication associated with tolterodine therapy.

Findings:

  • The patient's mental confusion resolved upon reduction of the tolterodine dosage to 1 mg twice daily.
  • Overactive bladder symptoms remained effectively controlled with the lower dosage.

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  • This suggests a dose-dependent relationship between tolterodine and cognitive side effects.

    • Implications:

    • Clinicians should be vigilant for cognitive side effects in patients treated with tolterodine.
    • Dosage adjustment may be a viable strategy to manage side effects while maintaining therapeutic efficacy.
    • Further research into the neurocognitive impact of anticholinergic drugs is warranted.