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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
Familial risk factors in autism
Michael Brimacombe1, Xue Ming, Amisha Parikh
1Department of Preventive Medicine, New Jersey Medical School University of Medicine and Dentistry of New Jersey, Newark 07101-1709, USA. brimacmb@umdnj.edu
Abstract:
Familial history risk factors in relation to autism were examined in a cohort of 164 autistic children referred to The Autism Center at New Jersey Medical School-University of Medicine and Dentistry of New Jersey, Newark, over a 2-year period (2001-2003). Information related to familial history was obtained from each family and reviewed by a clinician. It is shown that these families carry a higher overall burden of psychiatric and developmental illnesses compared to reported national levels. These families also carry a relatively high incidence of medical disorders, independently of developmental and psychiatric disorders. This work supports the underlying presence of genetic factors in the etiology of autism.
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