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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: Jul 13, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

Molecular basis for sunitinib efficacy and future clinical development.

Sandrine Faivre1, George Demetri, William Sargent

  • 1Service Inter-Hospitalier de Cancérologie (SIHC) Beaujon-Bichat and RayLab, Hôpital Beaujon, APHP and Denis Diderot University, 100 Boulevard du Général Leclerc, 92118 Clichy Cedex, France.

Nature Reviews. Drug Discovery
|August 11, 2007
PubMed
Summary

Sunitinib malate, a multitargeted tyrosine kinase inhibitor, shows efficacy in advanced renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumors. Its development highlights challenges in targeted cancer therapy, including response markers and resistance.

Related Experiment Videos

Last Updated: Jul 13, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Sunitinib malate (SU11248/Sutent) is a multitargeted tyrosine kinase inhibitor.
  • It exhibits significant anti-angiogenic and antitumour activities.
  • Approved for advanced renal cell carcinoma and imatinib-refractory gastrointestinal stromal tumors.

Purpose of the Study:

  • To summarize the discovery and development of sunitinib.
  • To discuss the multitargeted approach in cancer treatment.
  • To explore markers of response and resistance for future drug development.

Main Methods:

  • Review of preclinical and clinical data on sunitinib.
  • Analysis of efficacy in advanced renal cell carcinoma and gastrointestinal stromal tumors.
  • Discussion of challenges in multitargeted cancer therapy.

Main Results:

  • Sunitinib demonstrates definitive efficacy in specific cancer indications.
  • Regulatory approvals have been granted based on demonstrated efficacy.
  • Key issues for multitargeted therapy include response markers and resistance.

Conclusions:

  • Sunitinib represents a significant advancement in targeted cancer therapy.
  • Understanding resistance mechanisms is crucial for optimizing sunitinib's use.
  • Further research into multikinase inhibitors is warranted.