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Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Related Experiment Video

Updated: Jul 13, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Spontaneous splenic rupture in two patients with hematologic malignancy.

Tomas Szotkowski1, Romana Szotkowska, Zuzana Pikalova

  • 1Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacky University, University Hospital Olomouc, Czech Republic. tomast123@seznam.cz

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|August 11, 2007
PubMed
Summary

Spontaneous splenic rupture (SSR) is a rare but serious condition. It can occur even without prior injury and should be considered in patients with and without a history of malignancy.

Related Experiment Videos

Last Updated: Jul 13, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Area of Science:

  • Hematology
  • Oncology
  • Internal Medicine

Background:

  • Spontaneous splenic rupture (SSR) is an exceedingly rare event, with limited documented cases primarily in the form of case reports.
  • SSR is defined as splenic rupture occurring without any preceding trauma or injury.

Observation:

  • This paper details two unique cases of SSR diagnosed within a single year at a Hemato-oncology department.
  • The first case involved a patient undergoing chemotherapy for relapsed hairy cell leukemia.
  • The second patient presented with anemia and painful splenomegaly, later diagnosed with diffuse large B-cell lymphoma via spleen histology.

Findings:

  • The study highlights that SSR can manifest in patients with known hematologic malignancies.
  • Crucially, it also emphasizes that SSR can occur in individuals with no prior history of malignant disease.

Implications:

  • SSR necessitates consideration in the differential diagnosis for patients presenting with splenic rupture, irrespective of their medical history.
  • Raising awareness of SSR is critical for timely diagnosis and management, even in patients without a known cancer diagnosis.