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Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke

V Lucivero1, M Prontera, D M Mezzapesa

  • 1Department of Neurological and Psychiatric Sciences, University of Bari, Piazza G. Cesare 12, 1-70124, Bari, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|August 11, 2007
PubMed

Insights

Matrix metalloproteinases (MMPs) show different roles after ischaemic stroke. MMP-2 is linked to better recovery, while MMP-9 is associated with more severe stroke and worse outcomes.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9, have conflicting roles post-ischaemic stroke.
  • MMPs may be detrimental in acute phases but potentially beneficial during repair.

Purpose of the Study:

  • To investigate the relationship between MMP-2, MMP-9 levels, and stroke characteristics.
  • To explore the association with stroke subtypes, clinical recovery, and haemorrhagic transformation (HT).

Main Methods:

  • Plasma levels of MMP-2 and MMP-9 were measured in 29 ischaemic stroke patients.
  • Measurements were taken at day one and day seven post-stroke.

Main Results:

  • MMP-2 levels increased in lacunar strokes; higher basal levels correlated with better recovery.
  • MMP-9 levels increased in severe strokes; day seven levels correlated with worse clinical outcomes.
  • No significant association was found between MMP levels and haemorrhagic transformation.

Conclusions:

  • MMP-2 and MMP-9 exhibit distinct temporal patterns and prognostic implications after ischaemic stroke.
  • MMP-2 appears to be an early marker associated with favorable outcomes.
  • MMP-9 is a late marker linked to stroke severity and poorer prognosis.

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