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Updated: Jul 13, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
[The role of the serotoninergic system in the pathogenesis of experimental ulcerous colitis]
Abstract:
Ulcerous colitis was modeled in a rat experiment by introducing picrylsulfonic acid. The role of serotoninergic structures in the pathogenesis of ulcerous colitis was studied by preliminary administration of serotonin or spiperone, a 5-HT2 serotonin blocker. Spiperone was shown to inhibit the damaging action of picrylsulfonic acid during the first ten days of the beginning of modeling, and to accelerate reparative processes.
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