Related Experiment Video
Updated: Jul 13, 2026
09:01
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[Association between asthma and viral infections]
1Neumólogo Pediatra, Facultad de Medicina, Pontificia Universidad Católica, Chile. jacastro17@hotmail.com
Anales De Pediatria (Barcelona, Spain : 2003)
|August 19, 2007
Summary
Viral respiratory infections are strongly linked to asthma development and exacerbations. Key mechanisms include airway changes, immune responses, and genetic factors, guiding future prevention and treatment strategies.
Area of Science:
- * Immunology
- * Pulmonology
- * Pediatrics
Background:
- * Viral respiratory infections are the most common factor associated with asthma.
- * A clear temporal link exists between viral infections and acute asthmatic episodes.
- * The precise role of viral infections in asthma pathogenesis is not fully understood.
Purpose of the Study:
- * To explore the mechanisms linking viral respiratory infections to asthma.
- * To identify factors contributing to asthma or wheezing in children following viral infections.
Main Methods:
- * Review of existing literature on viral infections and asthma.
- * Analysis of potential causative mechanisms.
Main Results:
- * Four primary mechanisms implicated: airway function/size alterations, airway tone dysregulation, altered immune responses, and genetic variants.
- * These mechanisms are diverse and sometimes conflicting.
Conclusions:
- * Viral infections significantly impact asthma development and exacerbations.
- * Understanding these mechanisms is crucial for developing effective preventive and therapeutic strategies for asthma.
Related Concept Videos
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
01:24Asthma-III: Symptoms and Complications
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma