Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Laser balloon angioplasty.

W F Cheong1, J R Spears, A J Welch

  • 1Department of Internal Medicine, Wayne State University, Detroit, MI 48201.

Critical Reviews in Biomedical Engineering
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ancient and modern DNA track temporal and spatial population dynamics in the European fallow deer since the Eemian interglacial.

Scientific reports·2024
Same author

Cryptic lineage differentiation among Indo-Pacific bottlenose dolphins (Tursiops aduncus) in the northwest Indian Ocean.

Molecular phylogenetics and evolution·2018
Same author

The effect of temperature on the autofluorescence of scattering and non-scattering tissue.

Lasers in surgery and medicine·2012
Same author

Computer-aided retinal photocoagulation system.

Journal of biomedical optics·2012
Same author

Hybrid approach to retinal tracking and laser aiming for photocoagulation.

Journal of biomedical optics·2012
Same author

Optical low-coherence reflectometry to enhance monte Carlo modeling of skin.

Journal of biomedical optics·2012
Same journal

The Safety and Efficacy of Cardiac Stem Cell Therapy for Cardiovascular Disease: A Meta-Analysis of Randomized Controlled Trials.

Critical reviews in biomedical engineering·2026
Same journal

Local-Global-Graph Network-Based Biokey Generation with Electrocardiogram Signal and Lightweight Authentication in Cloud-Based Internet of Medical Things Networks.

Critical reviews in biomedical engineering·2026
Same journal

Diffusion Tensor Imaging for Brain Injury Assessment: Methodological Foundations and Clinical Insights.

Critical reviews in biomedical engineering·2026
Same journal

Novel Investigation of Hepatitis B Transmission Dynamics via Fractal-Fractional Operators of Variable and Constant Order with Memory Effects.

Critical reviews in biomedical engineering·2026
Same journal

An Improved YOLOv8-Based Object Detection Algorithm for Skin Diseases.

Critical reviews in biomedical engineering·2026
Same journal

A Numerical Comparison of Magnetic Nanoparticle Hyperthermia in Breast, Muscle, and Prostate Tumors.

Critical reviews in biomedical engineering·2025
See all related articles

Laser balloon angioplasty (LBA) uses heat and pressure to reopen blocked arteries, offering acute benefits. However, chronic lesion recurrence limits its use, primarily as an adjunctive therapy for difficult angioplasty cases.

Area of Science:

  • Cardiovascular Interventions
  • Biomedical Engineering
  • Laser Medicine

Background:

  • Conventional angioplasty (PTCA) uses intraluminal pressure alone.
  • Heavily occluded arterial lumens present challenges for PTCA.
  • Laser Balloon Angioplasty (LBA) offers a combined thermal and mechanical approach.

Purpose of the Study:

  • To define criteria for successful LBA based on in vitro experiments.
  • To present an optical-thermal model for dosimetry analysis.
  • To evaluate LBA's effectiveness in reopening arterial lumens.

Main Methods:

  • Utilized Nd:YAG laser light (1.06 microns) for circumferential irradiation.
  • Applied simultaneous heat and pressure via an inflated balloon.
  • Developed and validated a three-part optical-thermal model for parametric dosimetry.

Related Experiment Videos

Main Results:

  • LBA effectively seals disrupted flaps, remodels luminal surface, reduces recoil, and dehydrates thrombus.
  • Heating by LBA may reduce thrombogenicity at atherosclerotic sites.
  • Acutely satisfactory lumen remodeling was achieved, but chronic recurrence remains an issue.

Conclusions:

  • LBA demonstrates potential for reopening arterial lumens through combined thermal and pressure effects.
  • Current utility of LBA is primarily as an adjunctive procedure for challenging PTCA cases.
  • Future applications may include localized drug delivery with thermal adhesion.