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Related Experiment Video

Updated: Jul 13, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Malignancies following lung transplantation.

M Anile¹, F Venuta, D Diso

¹Department of Thoracic Surgery, University of Rome La Sapienza, Rome, Italy. m.anile@virgilio.it

Transplantation Proceedings

|August 19, 2007

Summary

Malignancy is a significant complication after lung transplantation, affecting 4.2% of patients. Early detection and a multidisciplinary approach are crucial for managing post-transplant cancers and improving survival.

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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

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Published on: January 19, 2019

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Last Updated: Jul 13, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

Area of Science:

Immunology
Oncology
Thoracic Surgery

Background:

Long-term survival after lung transplantation has improved.
Malignancy is a significant complication associated with long-term immunosuppression.
Understanding the incidence and types of cancers post-lung transplant is vital.

Purpose of the Study:

To report the experience with malignancies after lung transplantation.
To analyze the types of cancers, time to occurrence, and patient outcomes.
To emphasize the importance of a multidisciplinary approach in managing these cases.

Main Methods:

Retrospective review of lung transplant recipients from January 1991.
Analysis of patient demographics, immunosuppressive regimens, and cancer diagnoses.
Evaluation of treatment strategies and patient survival.

Main Results:

134 lung transplantations were performed in 128 recipients.
5 patients (4.2%) developed malignancy at a mean of 46.4 months post-transplant.
Cancers included laryngeal cancer, colon cancer, gastric cancer, non-Hodgkin lymphoma, and Kaposi's sarcoma.

Conclusions:

Malignancies are a critical concern following lung transplantation.
Management requires reducing immunosuppression and a multidisciplinary team approach.
Effective management can improve quality of life and long-term survival for transplant recipients.