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Updated: Jul 13, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Facial skeletal growth and timing of surgical intervention
1Section of Plastic and Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL 60637, USA. rreid@surgery.bsd.uchicago.edu <rreid@surgery.bsd.uchicago.edu>
Abstract:
Various forces and factors influence the development and maturation of the craniofacial skeleton. These encompass genetic and micro- and macro-environmental factors whose intricacies and interplay must be understood, recognized, and respected in the surgical planning and treatment of maxillofacial deformities. The theories of and experimentation with such factors, which dictate the timing of surgical intervention, are the focus of this article. The common procedures that make up the surgical armamentarium of the maxillofacial surgeon are catalogued in the setting of this developmental timeline.
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