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Updated: Jul 13, 2026
04:35
Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
Published on: December 27, 2024
Update on canine sinonasal aspergillosis
Dominique Peeters1, Cécile Clercx
1Department of Veterinary Clinical Sciences, Small Animal Internal Medicine, University of Liège, 4000 Liège, Belgium. dpeeters@ulg.ac.be
The Veterinary Clinics of North America. Small Animal Practice
|August 19, 2007
Summary
Sinonasal aspergillosis in dogs causes nasal discharge and may involve immune dysfunction. Topical antifungal treatments like enilconazole are effective, improving outcomes and reducing hospitalization.
Area of Science:
- Veterinary Medicine
- Mycology
- Immunology
Background:
- Sinonasal aspergillosis is a common condition in dogs, presenting as nasal discharge.
- Local immune dysfunction, potentially linked to interleukin-10 (IL-10) mRNA expression, is implicated.
- Current diagnostic standards rely on direct visualization or microscopic examination.
Purpose of the Study:
- To investigate the role of local immune dysfunction in canine sinonasal aspergillosis.
- To evaluate the effectiveness of noninvasive topical antifungal treatments.
Main Methods:
- Direct visualization via endoscopy.
- Cytology and histopathology for fungal element identification.
- Assessment of treatment outcomes with topical enilconazole or clotrimazole.
Main Results:
- Diagnosis confirmed by direct visualization or microscopic examination.
- Topical antifungal therapy demonstrated increased treatment success.
- Noninvasive treatments reduced morbidity and hospitalization duration.
Conclusions:
- Sinonasal aspergillosis is a significant cause of nasal discharge in dogs.
- Topical antifungal treatments offer a successful and less invasive therapeutic approach.
- Further research into immune dysfunction may elucidate disease mechanisms.
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