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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
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Angiotropic lymphoma: Associated chromosomal abnormalities.

Amit K J Mandal1, Louiza Savvidou, Robert M Slater

  • 1Department of Cardiology, Wexham Park Hospital, Slough, Berkshire, SL2 4HL, United Kingdom.

European Journal of Internal Medicine
|August 19, 2007
PubMed
Summary

Intravascular angiotropic lymphoma (IVL), a rare non-Hodgkin's lymphoma, can cause prolonged fevers. Bone marrow biopsy is crucial for early diagnosis of this often post-mortem identified disease.

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Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Intravascular angiotropic lymphoma (IVL) is a rare non-Hodgkin's lymphoma variant.
  • Diagnosis is frequently delayed, often occurring post-mortem.
  • IVL can present as pyrexia of unknown origin (PUO).

Purpose of the Study:

  • To report a case of IVL diagnosed via bone marrow biopsy in a patient with PUO.
  • To review chromosomal abnormalities associated with IVL.
  • To identify potential non-random chromosomal changes in IVL.

Main Methods:

  • Case presentation of a patient with pyrexia of unknown origin.
  • Bone marrow biopsy for histological and immunocytochemical examination.
  • Literature review of chromosomal abnormalities in IVL.

Main Results:

  • The patient was diagnosed with angiotropic lymphoma through bone marrow biopsy.
  • Confirmed previously reported non-random chromosomal changes in chromosomes 1, 6, and 10.
  • Identified potential non-random aberrations in chromosomes 4, 5, and 8.
  • Postulated the 6q21-24 region as a potential tumor suppressor gene locus.

Conclusions:

  • Bone marrow examination is vital for early diagnosis of IVL presenting as PUO.
  • Supports non-random chromosomal aberrations in IVL, suggesting a genetic basis.
  • Highlights the 6q21-24 region for further investigation in IVL pathogenesis.