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The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...

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Related Experiment Video

Updated: May 11, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Bone weighs in on obesity.

Clay F Semenkovich¹, Steven L Teitelbaum

¹Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA. teitelbs@wustl.edu

|August 19, 2007

Summary

This summary is machine-generated.

Bone plays a crucial role in regulating insulin and glucose levels, impacting energy metabolism. This discovery in mice offers a new perspective for treating obesity and diabetes.

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Area of Science:

Endocrinology
Metabolic disorders
Bone biology

Background:

Obesity, insulin resistance, and diabetes are complex metabolic disorders with limited therapeutic options.
Current therapies for these conditions often yield suboptimal outcomes.
Understanding the intricate regulation of energy metabolism is crucial for developing effective treatments.

Discussion:

Lee et al. (2007) investigated the role of bone in regulating systemic energy homeostasis.
The study identified bone as a key regulator of the insulin/glucose axis.
Findings suggest that bone tissue actively participates in metabolic control beyond its structural functions.

Key Insights:

Bone tissue directly influences insulin sensitivity and glucose regulation in mice.
This research establishes a novel link between skeletal biology and metabolic health.
The study provides a new framework for understanding and potentially treating metabolic diseases.

Outlook:

Future research should explore therapeutic strategies targeting bone to manage metabolic disorders.
Investigating the molecular mechanisms by which bone regulates metabolism is warranted.
Translating these findings from mice to humans could revolutionize the approach to obesity and diabetes treatment.