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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Outcome of single-chamber, ventricular pacemakers with transvenous leads implanted in children

Massimo Stefano Silvetti1, Fabrizio Drago, Simona Marcora

  • 1Servizio di Aritmologia, Dipartimento Medico-Chirurgico di Cardiologia Pediatrica, Bambino Gesù Pediatric Hospital, IRCCS, Piazza S. Onofrio 4, 00165 Roma, Italy. silvetti@opbg.net

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|August 19, 2007
PubMed

Insights

Ventricular demand, rate-responsive pacemakers (VVI/R PM) show good results in children, but long-term follow-up reveals a 19% failure rate, primarily due to lead issues.

Area of Science:

  • Pediatric Cardiology
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Ventricular demand, rate-responsive pacemakers (VVI/R PM) are frequently used in pediatric bradyarrhythmias.
  • Limited studies specifically address the long-term outcomes of VVI/R PM in children.

Purpose of the Study:

  • To evaluate the outcomes of VVI/R PM in a pediatric population.
  • To identify factors influencing pacemaker system survival in children.

Main Methods:

  • Retrospective analysis of 117 children implanted with VVI/R PM between 1990 and 2005.
  • Data collected on patient demographics, pacemaker type, lead characteristics, implantation details, and follow-up events.
  • Statistical analysis using log-rank test to identify risk factors for system failure.

Main Results:

  • A total of 117 children received VVI/R PM, with a mean age of 5.3 years.
  • The overall system failure rate was 19% over a mean follow-up of 7.8 years, predominantly due to lead malfunction (n=20).
  • Complications included lead dislodgement (5%) and subclavian vein occlusion (5%).

Conclusions:

  • VVI/R pacing demonstrates good short-term results in pediatric patients with bradyarrhythmias.
  • Long-term follow-up highlights a significant failure rate (19%), primarily attributed to lead-related complications.
  • Further research into lead design and implantation techniques may improve long-term VVI/R PM outcomes in children.
Abstract

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