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Published on: March 23, 2019
Relationships between oxidative stress response and virulence in Enterococcus faecalis.
Eliette Riboulet1, Nicolas Verneuil, Stéphanie La Carbona
1Laboratoire de Microbiologie de l'Environnement, EA 956 soutenue par l'INRA, IRBA, Université de Caen, Caen, France.
Journal of Molecular Microbiology and Biotechnology
|August 19, 2007
Summary
Enterococcus faecalis, a cause of hospital infections, faces oxidative stress during infection. This review explores its stress response and links it to virulence.
Area of Science:
- Microbiology
- Infectious Diseases
- Bacterial Pathogenesis
Background:
- Enterococcus faecalis is a Gram-positive bacterium and a significant cause of nosocomial infections.
- Bacteria, including E. faecalis, must overcome oxidative stress during infection.
- Understanding oxidative stress response is crucial for combating bacterial pathogens.
Purpose of the Study:
- To describe Enterococcus faecalis as an opportunistic pathogen.
- To provide an overview of the oxidative stress response and its regulation in E. faecalis.
- To explore the potential link between oxidative stress response and virulence in E. faecalis.
Main Methods:
- Literature review of Enterococcus faecalis.
- Analysis of oxidative stress response mechanisms.
- Synthesis of data on virulence factors and stress response.
Main Results:
- E. faecalis possesses specific mechanisms to combat oxidative stress.
- Regulation of the oxidative stress response involves complex pathways.
- Evidence suggests a correlation between enhanced oxidative stress response and increased virulence.
Conclusions:
- Enterococcus faecalis employs robust oxidative stress defense systems.
- The interplay between stress response and virulence is a key factor in E. faecalis pathogenesis.
- Targeting oxidative stress pathways may offer novel therapeutic strategies against E. faecalis infections.
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