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Related Experiment Video

Updated: Jul 13, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Citrulline and the gut.

Emmanuel Curis¹, Pascal Crenn, Luc Cynober

¹Laboratoire de Biomathématiques, Faculté de Pharmacie, Université Paris Descartes, Paris, France. emmanuel.curis@univ-paris5.fr

Current Opinion in Clinical Nutrition and Metabolic Care

|August 19, 2007

Summary

Citrulline, an amino acid produced in the gut, serves as a biomarker for short bowel function and is efficiently absorbed orally. Oral citrulline supplementation is more effective than arginine for increasing arginine levels.

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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

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Published on: October 20, 2018

Area of Science:

Gastroenterology
Nutritional Science
Biochemistry

Background:

Citrulline is a nonprotein amino acid and a key precursor to endogenous arginine.
The gastrointestinal tract is the primary site of citrulline production in humans.
Citrulline plays a dual role in gut physiology: as a biomarker and as a nutrient source.

Purpose of the Study:

To review the role of citrulline as a biomarker of short bowel function.
To discuss the significance of gut citrulline uptake for oral supplementation.
To explore recent advancements in understanding citrulline metabolism.

Main Methods:

Review of existing literature on citrulline metabolism, biomarkers, and gut absorption.
Analysis of pharmacokinetic studies related to oral citrulline supplementation.
Evaluation of clinical data on citrullinemia as a prognostic marker.

Main Results:

Citrullinemia effectively indicates compromised bowel function and can predict parenteral nutrition weaning.
Blood citrulline levels aid in decisions regarding parenteral versus enteral nutrition.
Citrulline is readily absorbed by the gut via multiple transporters in enterocytes.

Conclusions:

Oral citrulline supplementation is a highly efficient strategy for increasing arginine levels.
Citrulline's efficacy in oral supplementation surpasses that of arginine.
Citrulline holds significant potential as both a biomarker and a therapeutic agent in gastrointestinal health.