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Related Concept Videos

Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...

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Related Experiment Video

Updated: Jul 13, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

[Coagulation analysis in transplantation patients].

A Loew1, H Riess

  • 1Charité Campus Virchow Klinikum, Augustenburgerplatz 1, 13353 Berlin. andreas.loew@charite.de

Hamostaseologie
|August 19, 2007
PubMed
Summary

Organ transplantation can alter blood clotting (haemostasis) due to underlying conditions or the procedure itself. Liver transplant patients may develop or lose genetic clotting defects, complicating diagnostic interpretations.

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Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

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Last Updated: Jul 13, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

  • Hematology
  • Transplant Medicine
  • Genetics

Context:

  • Patients undergoing organ transplantation face risks of altered hemostasis.
  • Both the necessitating disorder and the transplant procedure can mask or induce hemostatic abnormalities.
  • The liver's role in producing coagulation factors makes liver transplantation particularly relevant to hemostatic defects.

Purpose:

  • To highlight the complexities of diagnosing coagulation disorders in transplant recipients.
  • To explain potential discrepancies between functional plasma tests and molecular findings in coagulation diagnostics.
  • To emphasize the need for careful interpretation of hemostatic findings in post-transplant patients.

Summary:

  • Organ transplantation can lead to acquired or inherited coagulation defects, especially after orthotopic liver transplantation.
  • Standard coagulation diagnostics may show discrepancies between plasma tests and molecular findings from peripheral blood cells.
  • Routine pre- or post-transplant screening for coagulation defects is generally not required due to rarity and lack of clinical impact for most disorders.

Impact:

  • Improved understanding of hemostatic changes in transplant patients.
  • Guidance for interpreting diagnostic tests in complex clinical scenarios.
  • Informed clinical decision-making regarding coagulation assessment in transplantation.