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Related Concept Videos

Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: Jul 13, 2026

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning
04:36

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

Published on: December 19, 2025

Therapeutic cloning: status and prospects.

Zhiming Han1, Catherine A Vandevoort, Keith E Latham

  • 1The Fels Institute for Cancer Research & Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA.

Current Opinion in Molecular Therapeutics
|August 19, 2007
PubMed
Summary

Therapeutic cloning using patient-specific embryonic stem cells (ESCs) shows promise for treating diseases. Advances in cloning and ESC differentiation suggest this approach may soon be feasible, despite technical and ethical challenges.

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Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
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Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

Related Experiment Videos

Last Updated: Jul 13, 2026

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning
04:36

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

Published on: December 19, 2025

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Bioethics

Background:

  • Embryonic stem cells (ESCs) hold significant potential for treating genetic, degenerative, and traumatic conditions.
  • Therapeutic cloning offers a method for generating patient-specific, histocompatible cells for transplantation.
  • Recent progress in cloning technology and human ESC differentiation indicates therapeutic cloning's potential feasibility.

Purpose of the Study:

  • To review the current status and feasibility of therapeutic cloning for generating patient-specific ESCs.
  • To identify technical challenges hindering the clinical application of therapeutic cloning.
  • To discuss the ethical considerations surrounding therapeutic cloning.

Main Methods:

  • Review of recent advancements in somatic cell nuclear transfer (SCNT) in non-human primates.
  • Analysis of techniques for establishing and differentiating human ESC lines.
  • Examination of ethical debates and regulatory landscapes concerning therapeutic cloning.

Main Results:

  • Improvements in cloned embryo production and ESC differentiation capabilities have been noted.
  • The potential for creating histocompatible ESCs via therapeutic cloning is increasingly supported by scientific evidence.
  • Significant technical and ethical hurdles remain to be addressed for clinical implementation.

Conclusions:

  • Therapeutic cloning presents a viable strategy for regenerative medicine, offering patient-specific cell therapies.
  • Further research is required to overcome technical obstacles and resolve ethical concerns.
  • The feasibility of therapeutic cloning is advancing, necessitating ongoing scientific and societal discussion.