Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Redefining epithelial progenitor potential in the developing thymus.

Simona W Rossi1, Ann P Chidgey, Sonia M Parnell

  • 1MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham Medical School, Birmingham, UK.

European Journal of Immunology
|August 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated reanalysis of genomic data for rare disease diagnostics at scale.

Nature medicine·2026
Same author

The germline landscape of pituitary adenomas: established and emerging predisposition genes.

The Journal of clinical endocrinology and metabolism·2026
Same author

Shaping the future of multiple myeloma with artificial intelligence and digital twins: from concept to clinic.

Frontiers in digital health·2026
Same author

Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness.

Nature·2026
Same author

NewbornsInSA multi-omic newborn screening: protocol for a prospective cohort study.

BMJ open·2026
Same author

Genomic Therapy Matching in Rare and Refractory Cancers.

JAMA oncology·2026
Same journal

Fast Generation of F(Ab')<sub>2</sub> Fragments From Human IgG Using Fc-Fused IgG-Degrading Enzyme.

European journal of immunology·2026
Same journal

Generation of Regulatory T Cells Against Islet Neoantigen.

European journal of immunology·2026
Same journal

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European journal of immunology·2026
Same journal

Special Issue: yEFIS 3rd Symposium.

European journal of immunology·2026
Same journal

CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16<sup>INK4A</sup> in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.

European journal of immunology·2026
Same journal

Induction of Humoral and Cellular Immunity After SARS-CoV-2 JN.1 Vaccination in Individuals With and Without Prior Infection.

European journal of immunology·2026
See all related articles

Researchers investigated thymic epithelial progenitor cells using the Mts24 marker. Both Mts24-positive and Mts24-negative cells can form functional thymic microenvironments supporting T cell development.

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Thymic epithelium is crucial for T cell development and repertoire selection.
  • The origin and persistence of thymic epithelial progenitor cells are debated.
  • Mts24 is a putative marker for these progenitor cells.

Purpose of the Study:

  • To redefine developmental stages of thymic epithelium.
  • To characterize Mts24-expressing cells in the developing thymus.
  • To assess the differentiation potential of thymic epithelial subsets.

Main Methods:

  • Utilized a panel of reagents including the Mts24 marker.
  • Examined thymic anlagen at embryonic day 12 (E12).
  • Performed thymus grafting experiments with distinct epithelial subsets.

Related Experiment Videos

Main Results:

  • Early thymic epithelial cells (E12) uniformly express Mts24.
  • Later stages show distinct Mts24-positive and Mts24-negative epithelial subsets.
  • Both Mts24(+) and Mts24(-) subsets can generate organized cortical and medullary microenvironments supporting T cell development.

Conclusions:

  • Clarifies developmental stages of thymic epithelial cells.
  • Provides insights into the functional potential of Mts24(+) and Mts24(-) thymic epithelial subsets.
  • Offers important information regarding markers for epithelial progenitors.