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Guinea Pig Maximization Test of tri-ethylene glycol mono-methacrylate
Takashi Akiyama1, Atsufumi Manabe, Chihiro Tani
1Department of Clinical Cariology and Endodontology, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ohta-Ward, Tokyo 145-8515, Japan. akiyama@senzoku.showa-u.ac.jp
Abstract:
The aim of this study was to evaluate tri-ethylene glycol mono-methacrylate (TEGMA) in terms of dermatological allergic reaction using a Guinea Pig Maximization Test. Skin reaction was evaluated according to the criteria of International Contact Dermatitis Research Group. TEGMA, as a constituent in new primers, has been reported to contribute to a priming ability similar to that of highly purified glyceryl mono-methacrylate (GM). In this study, it was found that its adverse effect was less than that of 2-hydroxy ethyl methacrylate (2-HEMA), but similar to that of highly purified GM. In conclusion, it was anticipated that TEGMA would hereafter replace 2-HEMA as a primer, as it posed a lower risk of triggering dermatological allergic reaction.
