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Updated: Jul 13, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Expanding the bioheat equation to include tissue internal water evaporation during heating
Deshan Yang1, Mark C Converse, David M Mahvi
1Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53706, USA.
Abstract:
We propose a new method to study high temperature tissue ablation using an expanded bioheat diffusion equation. An extra term added to the bioheat equation is combined with the specific heat into an effective (temperature dependent) specific heat. It replaces the normal specific heat term in the modified bioheat equation, which can then be used at temperatures where water evaporation is expected to occur. This new equation is used to numerically simulate the microwave ablation of bovine liver and is compared to experimental ex vivo results.
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