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Updated: Jul 13, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
Published on: November 4, 2016
Dendritic cells and the immunopathogenesis of systemic lupus erythematosus
Seetha Monrad1, Mariana J Kaplan
1Division of Rheumatology, University of Michigan, 5520 MSRBI, Box 0680, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
Abstract:
Over the last decade, the role of dendritic cells (DCs) in the immunopathogenesis of systemic lupus erythematosus (SLE) has become apparent. As unique mediators of both tolerance and immunity, aberrant myeloid and plasmacytoid DC function can promote autoimmune responses via a number of mechanisms and proinflammatory pathways. This review provides an overview of DC function, the potential role of DCs in promoting autoimmune responses in SLE, and how other abnormalities in lupus can lead to an enhanced engagement of DCs in immune responses. How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored.
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